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Citation Details

The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis


Authors >Govek EE, >Newey SE, >Akerman CJ, >Cross JR, >Van der Veken L, >Van Aelst L
In >Nat Neurosci (2004) 7(4): 364-372
Cells used in publication Neuron, hippo/cortical, rat
   Rat hippocampal/cortical neurons
   Neural/Glial Cells
   Primary Cells
   Species: rat
   Tissue Origin: brain
Substrate Plasmid (general)
Substrate Description antisense expression vector
Topics >Antisense
>Cell morphology/cytoskeleton
>Differentiation of nucleofected cells
>Diseases (e.g. HIV)
>Hereditary diseases
>Intercellular interaction/communication
>Signal transduction
Research Area >Neurobiology

Research Field

Oligophrenin-1, a Rho-GTPase activating protein that is absent in a family affected with nonspecific X-linked mental retardation (MRX) is required for dendritic spine morphogenesis.

Nucleofection Experiments

An antisense construct for knock-down of oligophrenin-1 is nucleofected into primary rat hippocampal neurons.

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