amaxa eNews #3

Welcome to amaxa eNews #3!

This issue provides you with an update on RNAi applications and the opportunities Nucleofector Technology offers in this field. Enjoy reading!

And if you like amaxa eNews recommend it to your friends and colleagues.

Your amaxa team

Hot Topic: Strategies for Reducing Off-target Effects

Off-target effects can distort silencing results with false positive phenotypes or complicate interpretation due to inconsistent results. Such effects can be induced by sequence-dependent silencing of unintended targets or by unspecific effects of dsRNA. Our collaboration partner Dharmacon, Inc. has shown that the use of high quality siRNA reagents can help reducing these effects.

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Product Information

Whether you are transfecting siRNA oligonucleotides, shRNA vectors or miRNA substrates into hard-to-transfect cell lines or primary cells:

Nucleofector Technology offers you highly efficient non-viral delivery for any RNAi substrate combined with high flexibility – from single samples to library screening.

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Application Note

Delivering siRNA reagents or libraries into cells that have been considered intractable to lipid reagent-based transfection methods:

A guideline for establishing siRNA experiments by combining Dharmacon's highly functional SMARTpool siRNA reagents with the amaxa Nucleofector 96-well Shuttle System - a unique and powerful method.

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Webinar

amaxa's online user webinar on 'Nucleofection and RNAi' was a great success. Watch a complete replay and get important tips and latest news from our R&D and Scientific Support Teams on e.g.:

	Efficient knockdown in hard-to-transfect cell lines and primary cells.
	Critical parameters for establishing siRNA experiments, e.g. importance of concentration and time course.

View Webinar

Related FAQs

Our frequently asked questions list contains useful tips and hints as well as background information on the nucleofection of RNAi substrates.

View List

Related Citations

More than 400 citations attest to our Nucleofector Technology being a valuable tool for RNAi applications.

View List to see a selection of them.
To see all citations visit our Citations Database.

View List

New RNAi Flyer!

Update yourself on the Nucleofection of different RNAi substrates in hard-to-transfect cells.

Download new RNAi Flyer

siRNA calculator

Use our siRNA calculator to determine the correct amount of siRNA needed for your experiment.

Meetings & Shows

Meetings and shows at which amaxa will be present from August to December 2007.

amaxa's Website

Next Issue

amaxa eNews #4
coming in November 2007

Hot Topic: Neuroscience

Next Online User Webinar

To attend amaxa's next online user webinar on 'Nucleofection of Primary Blood Cells' register here.

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The Nucleofector Technology, comprising Nucleofection Process, Nucleofector Device, Nucleofector Solutions, Nucleofector 96-well Shuttle System and 96-well Nuleocuvette plates and modules is covered by patent and/or patent pending rights owned by amaxa AG.

amaxa, Nucleofector, nucleofection, maxGFP, 96-well Shuttle and Nucleocuvette are either registered trademarks or trademarks of amaxa AG in the U.S. and/or Germany and/or other countries. Dharmacon and SMARTpool are registered trademarks of Dharmacon, Inc.. Other product and company names mentioned herein are the trademarks of their respective owners.

amaxa disclaims all warranties, whether expressed or implied, including any warranty as to the quality, accuracy, safety, or suitability of the information provided in this e-newsletter for any particular purpose. Any use of the information contained on any page of this e-newsletter is evidence of agreement with these terms of use.